Essential Amino Acid Prophylaxis against Gradual Protein Depletion with Age

GŁnter Valet

Protein Depletion: It is accepted that muscle strength decreases with age due to a decrease of muscle protein (sarcopenia) . Individuals become weaker, collapse more easily and may suffer bone fractures. This limits their activities and requires frequently costly nursing care.

Essential Amino Acids: The regular prophylactic taking of essential amino acids at higher age is a simple, efficient, side effect free and cost effective measure to stop gradual protein depletion. Effects of Essential amino acids are typically investigated under standardized conditions in retirement and nursing homes (1, 2, 3). It seems, however, equally important to investigate elderly humans prior to entry into these institutions to keep them mobile as long as possible.

Gradual Protein Depletion: Musle and other body proteins consist of 20 different amino acids, eight of them, the "essential amino acids" cannot be synthesized by the organism. Essential and other amino acids are eaten as animal or vegetal protein at a daily requirement of approximately 1g protein/kg body weight, cleaved into amino acids in the gut, resorbed via the intestinal wall followed by protein synthesis in the body tissues. This functions well until the age of 60-70 years. Protein synthesis decreases afterwards despite continuation of usual food intake. Vital functions like blood and immune cell production, regeneration of intestinal and skin epithelium continues, nevertheless immune defense decreases, digestive problems may arise and the skin is less well regenerated than before. It becomes thinner (cigarette paper skin) with a tedency of keratosis formation and the emergence of age spots. Required, but missing essential amino acids are either taken from muscle protein degradation or less new muscle protein is snthesized, leading to a gradual protein depletion of the organism with the consequences described above.

Nutritional Protein Increase: Increase of protein intake is usually accompanied by increased fat like in meat, ham, sausage, fish, cheese, yoghurt, eggs or nuts. Continuous eating of low fat quark is not tasty and sometimes not well tolerated (digestiv problems). Commercial protein drinks or shakes (soja, whey) do not necessarily correspond in their amino acid composition to the indiviual requirements, they may strain kidnea metabolism and are not always well tolerated (allergies, additives).

Deficit Compensation (Sponge like): Body protein synthesis can alternatively be stimulated by providing sufficient quantities of essential amino acids corresponding to approximately 30-40% of the daily requirements as supplement to the usual nutrition. Additionally required non essential amino acids are synthesized by the organism without side effects from the ingested carbohydrate and fat molecules in the required quantities. In case of excess essential amino acids, they may be transformed into other molecules, used for energy generation or excreted in small quantities in the urine.

No Side Effects and Inexpensive: No side effects are observed upon ingestion of physiologic amounts (30-40% of total requirement) of essential amino acids. The intestinal mucosa cannot differentiate between supplemented amino acids and amino acids obtained from intestinal protein degradation. The therapy is comparatively economic with 14-18Euro/20 days that is less than 1 Euro/day. Essential amino acids are nutrition supplements and no medication. They can be obtained in stationary or on-line pharmacies ( z.B.) and are of vegetal origin. The effects of 3x2 capsules prior to breakfast, supper and dinner for myself as well as for my wife, both aged above 80 years was unexpectedly positive, with observable effects beginning at 8-14 days after start. Nutrition continued to be diversified and self prepared, with 40-50g protein/day at body mass indices (BMI) of 25.1 and 20.0. No home, fitness or eldery gymnastic training was performed and no anabolica or protein preparations were taken. Skin converted after approximately 14days from thin, pale and dry to well perfused with "vital" aspect. keratoses diminished after sveral weeks and age spots faded significantly.

Increase of Muscle Strength without Training: Concerning muscle strength One may think that personal estimation of muscle strength represents imagination rather than reality. Regarding the images of the split logs work (Fig.1) at the end of April 2022 makes this, however, unlikely. 20-30 stere of split logs are prepapred at similar living conditions since 13 years (1 stere equals approximately 0,85m3 or around 850kg in the case of fresh beech wood) by two persons without outside or family help. Wood is prepared in daily quantities of 1,5-2,0 steres, loaded, driven home, unloaded and piled up. During the past years one day of rest was typically required after one or two consecutive days, while this year on 3 consecutive days before and after the easter holidays six trailers of split logs were prpared and brought home without rest. The tree trunks in the left image were converted in this way into the split logs pile on the right image. The image in the middle shows 50cm long trunk sections of up to 75cm diameter weighing up to 200kg per piece. They were split by metal wedges into four or six pieces. The meter (2m) in the right image serves as reference for the wood pile. Taking four month 30-40% of the daily requirement of essential amino acides has clearly increased physical performance (tonicity) as compared to earlier years.

Conclusions: The potential for the generalization of the presented results could be investigated with self supporting elderly people or in retirement homes by providing prophylactic essential amino acids while determining their physical capacities without unusual training efforts. This may turn into an important focus for geriatry in the effort of mobility conservation for the elderly. The prophylactic taking of essential amino acids may also be valuable for accelerated protein synthesis in people affected by protein malnutrion in developping countries.

trunk heap  April 2022  split logs preparation April 2022  final split logs pileup April 2022

Fig.1 Work up of around 8,5m3 freshly cut beech trunks
corresponding to about 8.500kg wood within six working days (click onto image to enlarge)

1. Kobayashi H. Age-related sarcopenia and amino acid nutrition.
J Phys Fitness Sports Med. (2013) 2: 401-407.
2. Barnes K, Masud T.. Sarcopenia and amino acids
Geratric Medicine (2016)
3. Kobayashi H. Amino Acid Nutrition in the Prevention and Treatment of Sarcopenia
J Pharmaceut Soc Japan, (2018) 138:1277-1283

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