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6th ESACP Congress, Heidelberg, April 7-11, 1999 |
A046
Ectopic development of fetal organs was proved possible and multiphasic.
DEGENERATIVE AND REGENERATIVE PROCESSES IN FETAL ORGAN ECTOPIC GROWTH
Coulic V, Hustin J, De Vuyst M, Deprez C, Staroukine M, Deltenre M
CHU Brugmann, Brussels, Belgium
AIM: To check the relations between degenerative and regenerative features
at different moments of this development.
MATERIAL AND METHODS: Intestines, stomach, pancreas, heart from donors
aged 16-20 days i.u. were implanted into a subcutaneous ear pouch of 120
syngenic adult rats and mice. Optic and electron microscopy, histochemistry
and immunoassay were provided.
RESULTS: 1) During the 1st week in all grafted organs degenerative
processes were predominant and affected the most differentiated elements.
A mild inflammatory reaction was noted. 2) At weeks 2-4 regeneration was
predominant: mitosis, multiplication of undifferentiated cells, their
further maturation and organization into tissue. However intestinal muscular
layers remaied myoblastic; the gastric graft contents was not restored until
stimulation of the mucosa by BSA was provided; pancreas was represented
only by tubular structures and isolated endocrine cells with an important
inflammatory reaction.The heart implant was constituted by a myoblastic
cuff surrounding endothelial-like cells. 3) Later one implant showed a
more or less evident degradation but proliferation was always present. Some
pathology was noted: retention kysts, ulceration (bovel and stomach),
polyps (colon), adipous degeneration (heart, pancreas).
CONCLUSION: Fetal organ ectopic growth seems an interesting model of
physiological and pathological regeneration and degeneration, usually
the same as in humans.