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6th ESACP Congress, Heidelberg, April 7-11, 1999 |
A128
In primary superficial bladder cancer ploidy status was determined by
image cytometry and related to the risk of early recurrence and tumor
progression. 80 patients with stage pTa (n=62) and pT1 (n=18) bladder
cancer were included. Total observation time was 2.5 years (minimum 18 months).
DNA measurements were performed by image cytometry on imprints of
transurethral tumor resection (TUR) material. DNA aneuploidy was identified
by interpretation of stemline.
Ploidy analysis of the primary tumors revealed 56% peridiploid, 13%
peritetraploid and 31 % aneuploid DNA patterns. There were significant
correlations between ploidy and the histologic grade and the pathological
stage showing increased rates of non-diploidy in G2/G3 tumors compared to
G1 (p<0.01) and of non-diploidy in pT1 tumors compared to pTa (p<0.005).
In 44 patients local tumor recurrence was observed. Recurrence rate of the
aneuploid cases was nearly 2.5 fold higher than that of the peridiploid cases
(88% vs. 35,6%; p<0.005). Concerning the association between the rate of
recurrence and histologic grade or pathological stage, no significant
correlations became obvious (p=0.1048 and p=0.2584, respectively). In 29,5%
of patients with recurrent tumors (13/44) a stage progression was found.
This occurred exclusively in peritetraploid (1/6) and aneuploid (12/22)
tumors (p<0.005). On the other hand, no significant relation between
progression and initial histologic grade (p=0.1817) or pathological stage
(p=0.6857) was found.
The results of this study emphasize the prognostic potential of ploidy
in superficial bladder cancer.
DNA-PLOIDY IN SUPERFICIAL BLADDER CANCER AND CORRELATION TO
EARLY RECURRENCE AND PROGRESSION
Spiethoff A 1, Koser M 2, Lippert CM 2, Bohrer MH 1
1) Patholog.Institut, 2) Urolog.Klinik des Klinikums Ludwigshafen,
Germany