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6th ESACP Congress, Heidelberg, April 7-11, 1999 |
A056
The aim of the study was to detect chromosomal imbalances in different stages
of tumor progression. The numerical chromosomal aberrations were examined by
CGH in sixty breast cancers. The DNA-ploidy was estimated by image cytometry.
The number of chromosomal aberrations increase from the peridiploid via the
peritetraploid to the aneuploid tumors. The aneuploid breast cancers exhibit
the highest number of chromosomal losses, including also regions harboring
tumor suppressor genes like p53, DCC and DCP. The peritetraploid group was
characterized by a similar number of chromosomal gains and losses of tumor
suppressor gene loci . The gains in the peritetraploid tumors include also
regions of oncogenes like c-myc and c-erb-B2. An increase of tumor size was
associated with gain on 8q and losses on 12q. Tumors with lymphnode
metastases exhibit also gains on 8q, here including the region of c-myc and
additionally losses on 18q. The gene locus of c-erbB-oncogene and the distal
region of 8q were gained in breast can cers with a Bloom-Richardson grade 3.
In conclusion, the progression of breast cancer is accompanied by an increase
of chromosomal aberrations with gains of regions harboring oncogenes and
losses including tumor suppressor genes, too. The gain of 8q, including the
c-myc oncogene, seems to be a common features during the tumor progression of
mammary gland. Other chromosomal aberrations are associated with different
features of a malignant disease, reflecting the multiple genomic influences
on the tumor phenotype.
DIFFERENT PATTERN OF CHROMOSOMAL ABERRATIONS IN THE PROGRESSION OF BREAST
CANCER
Friedrich K, Scheithauer J, Haroske G, Dimmer V, Meyer W, Theissig F,
Kunze KD
Institute of Pathology Hospital of University of Technology, Dresden,
Germany